Investigating the ease of identifying drug concentrations of extemporaneously prepared sertraline.

 

WRITING AN INTRODUCTION FOR MY DISSERTAION THESE ARE ALL THE SUB-TITLES THAT NEED TO BE EXPLAINED FURTHER. ROUGHLY A PARAGRAPH FOR EACH SUB HEADING.

 

USE EXAMPLES FROM JOURNALS SUCH AS:

 

The study conducted by Rosenburg et al, showed that out of the 22 prescriptions for half tablet only 7 tablets actually met the United States Pharmaceopia (USP) standards for the weight uniformity. It can be evaluated that splitting the tablet or capsule is an inaccurate way of administering a dose to a patient and can lead to fatal consequences.

(MAKE SURE EACH BIT IS HAVARD REFRENCED).

REFER TO BRITISH PHARMACEOPIA

  Policies protocol for extemporaneous preparation

• Limitations of extemporaneous preparations
• Unlicensed drugs
• Off label medicines
• Legal review
• Problems with extemporaneous products
• Specials- extemporaneous not sterile formulations
• Risks with drugs
• Legislation laws- EU for paediatric formulations
• Procedure for pharmacists
• Stability issues
• Chemical instability/physiological factors for paedriatics
• Safety considerations with excipients
• Quality assurance and safety
• Excipients/preservatives
• Extemporaneous preparations of drugs/ increase stability of extemporaneous products
• Lack of stability studies
• Lack of bioavailability pharmacokinetic and safety information
• Reporting of adverse reactions to medicines
• Safety/ limitations of extemporaneous products
• Paediatric patients/ geriatric patients

  Introduction into the drug sertraline

• Chemical structure of sertraline
• Excipients of setraline
• Pharmokinetics(ADME) /pharmodynamics/physical/chemical/properties
• Side effects of sertraline and physiochemical properties
• Degradates of sertraline
• Extemporaneous formulation of setraline
• (any additional info)- what it reacts it
• Mechanism of action

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