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Dissertation writing investigating the ease of identifying drug concentrations of extemporaneously prepared sertraline

Investigating the ease of identifying drug concentrations of extemporaneously prepared sertraline.

 

WRITING AN INTRODUCTION FOR MY DISSERTAION THESE ARE ALL THE SUB-TITLES THAT NEED TO BE EXPLAINED FURTHER. ROUGHLY A PARAGRAPH FOR EACH SUB HEADING.

 

USE EXAMPLES FROM JOURNALS SUCH AS:

 

The study conducted by Rosenburg et al, showed that out of the 22 prescriptions for half tablet only 7 tablets actually met the United States Pharmaceopia (USP) standards for the weight uniformity. It can be evaluated that splitting the tablet or capsule is an inaccurate way of administering a dose to a patient and can lead to fatal consequences.

(MAKE SURE EACH BIT IS HAVARD REFRENCED).

REFER TO BRITISH PHARMACEOPIA

  Policies protocol for extemporaneous preparation

  • Limitations of extemporaneous preparations
  • Unlicensed drugs
  • Off label medicines
  • Legal review
  • Problems with extemporaneous products
  • Specials- extemporaneous not sterile formulations
  • Risks with drugs
  • Legislation laws- EU for paediatric formulations
  • Procedure for pharmacists
  • Stability issues
  • Chemical instability/physiological factors for paedriatics
  • Safety considerations with excipients
  • Quality assurance and safety
  • Excipients/preservatives
  • Extemporaneous preparations of drugs/ increase stability of extemporaneous products
  • Lack of stability studies
  • Lack of bioavailability pharmacokinetic and safety information
  • Reporting of adverse reactions to medicines
  • Safety/ limitations of extemporaneous products
  • Paediatric patients/ geriatric patients

  Introduction into the drug sertraline

  • Chemical structure of sertraline
  • Excipients of setraline
  • Pharmokinetics(ADME) /pharmodynamics/physical/chemical/properties
  • Side effects of sertraline and physiochemical properties
  • Degradates of sertraline
  • Extemporaneous formulation of setraline
  • (any additional info)- what it reacts it
  • Mechanism of action

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