{"id":9862,"date":"2023-10-05T16:04:55","date_gmt":"2023-10-05T05:04:55","guid":{"rendered":"https:\/\/casestudyhelp.com\/sample-questions\/?p=9862"},"modified":"2023-10-05T16:06:24","modified_gmt":"2023-10-05T05:06:24","slug":"biol-600-bioinformatics-population-genetics-human-disease-and-genetic-drift","status":"publish","type":"post","link":"https:\/\/casestudyhelp.com\/sample-questions\/biol-600-bioinformatics-population-genetics-human-disease-and-genetic-drift\/","title":{"rendered":"BIOL 600 Bioinformatics: Population Genetics, Human Disease, and Genetic Drift"},"content":{"rendered":"<h2><strong>BIOL 600 Bioinformatics: Population Genetics, Human Disease, and Genetic Drift\u00a0<\/strong><\/h2>\n<p><strong>Assignment Details:-<\/strong><\/p>\n<ul>\n<li><strong>Words: 3000<\/strong><\/li>\n<\/ul>\n<blockquote><p>Are you seeking the best BIOL 600 Bioinformatics: Population Genetics, Human Disease, and Genetic Drift<a href=\"https:\/\/casestudyhelp.com\/sample-questions\/\" target=\"_blank\">\u00a0assignment questions and answers<\/a>? Don\u2019t worry; <a href=\"https:\/\/casestudyhelp.com\/\" target=\"_blank\">casestudyhelp.com<\/a> is here to solve your problem. We have a professional team of writers. We only offer 100% plagiarism-free unique content. Our service is very fast, and we are responsible for completing your assignment on time. You must try our <a href=\"https:\/\/casestudyhelp.com\/assignment-writing-services.html\" target=\"_blank\">assignment writing service<\/a>.<\/p><\/blockquote>\n<p><a title=\"Order now\" href=\"https:\/\/casestudyhelp.com\/MyOrder.php\" target=\"_blank\"><img decoding=\"async\" loading=\"lazy\" class=\" size-full wp-image-9029 aligncenter\" src=\"https:\/\/casestudyhelp.com\/sample-questions\/wp-content\/uploads\/2022\/12\/order-now.jpg\" alt=\"Order Now\" width=\"700\" height=\"87\" srcset=\"https:\/\/casestudyhelp.com\/sample-questions\/wp-content\/uploads\/2022\/12\/order-now.jpg 700w, https:\/\/casestudyhelp.com\/sample-questions\/wp-content\/uploads\/2022\/12\/order-now-300x37.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Part A. The basics of HWE.<\/strong><\/h3>\n<p><strong>Q1.<\/strong> There are two alleles, A and a, at the locus MX2. The \u2018A\u2019 allele is dominant to \u2018a\u2019. At Duquesne there is a<\/p>\n<p>population of 9,344 students. The frequency of A, p, is 0.75 and the frequency of q is 0.25. Assuming HWE at this gene, what would you predict the number of students is with each of the possible genotypes:<\/p>\n<p>Students at Duquesne with AA: _________<\/p>\n<p>Students at Duquesne with Aa: ___________<\/p>\n<p>Students at Duquesne with aa: ___________<\/p>\n<h3><strong>Part B. Applying HWE to estimate carriers for a disease.<\/strong><\/h3>\n<p>Every child born in the US is tested for a disease called Phenylketonuria.<\/p>\n<p><strong>Q2.<\/strong> What is PKU? Provide a brief description of the disease. Why are all babies in the US screened for PKU?<\/p>\n<p><strong>Q3.<\/strong> PKU is inherited in recessive mendelian pattern. This means that individuals born with PKU are a homozygotes for the recessive allele that causes this disorder. If the frequency of PKU in the US is 1:25,000 and we assume this is similar at Duquesne, how many students at Duquesne are potentially carriers for this disease? Show how you solved this.<\/p>\n<h3><strong>Part C. Effect of Genetic Drift on Allele Frequencies<\/strong><\/h3>\n<p>Go to the website app that models allele frequencies over generations in HWE. On the lefthand upper part of the page, you are going to use following number of individuals specified in the table below. In each of these, the starting frequency of the alleles is p = 0.5 and q = 0.5. Double click in the number cells and type in the correct number, then hit \u2018set up\u2019, then \u2018go forever\u2019 to start simulation. Click \u2018go forever\u2019 again to = stop the simulation at 500 generations (does not have to be exact, try to get as close to 500 as you can), then in the three tables below record the exact generation you ended on, the frequency of the recessive homozygotes f(aa). if one of the alleles was fixed before 500 generations, look up the number that happened for that run in the allele frequency plot with your mouse.\u00a0 Finally, calculate both allele frequencies p and q. Repeat simulations 5 times for each population size below.<\/p>\n<h3><strong>Total Population Size: 128 individuals<\/strong><\/h3>\n<table>\n<tbody>\n<tr>\n<td width=\"90\"><strong>Males<\/strong><strong>AA: 16, Aa: 32, aa: 16<\/strong><\/td>\n<td width=\"91\"><strong>Females<\/strong><strong>AA: 16, Aa: 32, aa: 16<\/strong><\/td>\n<td width=\"113\"><strong>Generations simulation stopped<\/strong><\/td>\n<td width=\"58\"><strong>F(aa)<\/strong><\/td>\n<td width=\"46\"><strong>p<\/strong><\/td>\n<td width=\"47\"><strong>q<\/strong><\/td>\n<td width=\"180\"><strong>If fixation occurred prior to end of run, what generation did that happen<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 1<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 2<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 3<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 4<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 5<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><\/td>\n<td width=\"91\">Mean<\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3>\u00a0<strong>Total Population Size: 64 individuals<\/strong><\/h3>\n<table>\n<tbody>\n<tr>\n<td width=\"90\"><strong>Males<\/strong><strong>AA: 8, Aa: 16, aa: 8<\/strong><\/td>\n<td width=\"91\"><strong>Females<\/strong><strong>AA: 8, Aa: 16, aa: 8<\/strong><\/td>\n<td width=\"113\"><strong>Generations simulation stopped<\/strong><\/td>\n<td width=\"58\"><strong>F(aa)<\/strong><\/td>\n<td width=\"46\"><strong>p<\/strong><\/td>\n<td width=\"47\"><strong>q<\/strong><\/td>\n<td width=\"180\"><strong>If fixation occurred prior to end of run, what generation did that happen<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 1<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 2<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 3<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 4<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 5<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><\/td>\n<td width=\"91\">Mean<\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3><strong>\u00a0Total Population Size: 32 individuals<\/strong><\/h3>\n<table>\n<tbody>\n<tr>\n<td width=\"90\"><strong>Males<\/strong><strong>AA: 2, Aa: 4, aa: 2<\/strong><\/td>\n<td width=\"91\"><strong>Females<\/strong><strong>AA: 2, Aa: 4, aa: 2<\/strong><\/td>\n<td width=\"113\"><strong>Generations simulation stopped<\/strong><\/td>\n<td width=\"58\"><strong>F(aa)<\/strong><\/td>\n<td width=\"46\"><strong>p<\/strong><\/td>\n<td width=\"47\"><strong>q<\/strong><\/td>\n<td width=\"180\"><strong>If fixation occurred prior to end of run, what generation did that happen<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 1<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 2<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 3<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 4<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\">Replicate 5<\/td>\n<td width=\"91\"><\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<tr>\n<td width=\"90\"><\/td>\n<td width=\"91\">Mean<\/td>\n<td width=\"113\"><\/td>\n<td width=\"58\"><\/td>\n<td width=\"46\"><\/td>\n<td width=\"47\"><\/td>\n<td width=\"180\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Q4.<\/strong> After watching these simulations, why is the effect of small population size on allele frequencies called \u2018genetic drift\u2019?<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Q5.<\/strong> What is the relationship between population size and how rapidly the allele frequencies change? Where does this come from?<\/p>\n<p><strong>\u00a0For REF\u2026 Use:<span style=\"color: #808000\">#getanswers2002570<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<script type=\"text\/javascript\" charset=\"utf-8\" src=\"http:\/\/w.sharethis.com\/widget\/?wp=6.2.9\"><\/script>","protected":false},"excerpt":{"rendered":"<p>BIOL 600 Bioinformatics: Population Genetics, Human Disease, and Genetic Drift\u00a0 Assignment Details:- Words: 3000 Are you seeking the best BIOL 600 Bioinformatics: Population Genetics, Human Disease, and Genetic Drift\u00a0assignment questions and answers? Don\u2019t worry; casestudyhelp.com is here to solve your problem. We have a professional team of writers. We only offer 100% plagiarism-free unique content. 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